anarchodelphis , to Random stuff
@anarchodelphis@zeroes.ca avatar

UPDATED: variants.

Only 26 samples have been uploaded for 5/5 - 5/11. Of those, KP.2.* represented 19.2% (⬆️ 14% of 513, 4/28 - 5/4; ⬆️ 8.3% of 636, 4/21 - 4/27), & KP.3 26.9% (⬆️ 24%, w.o. 4/28; ⬆️ 16.8%, w.o. 4/21).

Of the samples collected in Canada on these weeks, the prevalence of significant variants/lineages are as follows:

  • 5/5 - 5/11 (few samples) -
    • JN.1.* (incl. JN.1.4., ".1.7., KP.1.* - KP.3, JN.1.16.): 100%
    → JN.1.4.
    : 7.7%
    → JN.1.11.1.* (incl. KP.1.* - KP.3): 53.8%
    → KP.2: 19.2%
    → KP.3: 26.9%

  • 4/28 - 5/4 -
    • JN.1.* (incl. JN.1.1., ".1.2, ".1.4., KV.2, JN.1.7.* - ".1.9.2, LB.1, JN.1.10, ".1.11.1, KP.1.* - KP.4.1, JN.1.13., KS.1, JN.1.16., LA.1, JN.1.18.2, ".1.20, ".1.22, ".1.25.1, ".1.26, KW.1.1, JN.1.30, ".1.32, ".1.40): 94.9%
    → JN.1.4.: 12.9%
    → JN.1.11.1.
    (incl. KP.1.* - KP.4.1): 48.9%
    → KP.2.* (incl. KP.2.1 - KP.2.3): 14%
    → KP.3: 24%

X.X.* in text = X.X & descendants.

X.X.* in graph = all descendants of X.X, except for ones that have their own segment of the week’s bar. Please see "Notes on Usage" section.

https://anarchodelphis.tumblr.com/CanadaVariants

tomkindlon , to covid19 group
@tomkindlon@disabled.social avatar

(pay wall)
"Parents of children with claim they have been accused of faking or exaggerating their child’s illness, leading to social services’ involvement and... court cases and the threat of the child’s removal from the home."

https://inews.co.uk/news/parents-children-long-covid-accused-making-up-3034629

@longcovid

@covid19
@novid

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  • tomkindlon OP ,
    @tomkindlon@disabled.social avatar

    2/

    The UK ME Association have posted some extracts:

    "Parents of children with accused of making it up: Doctors and parents say children are being threatened with being taken into care as medics struggle to diagnose their conditions and families are placed under suspicion"

    https://meassociation.org.uk/2024/05/parents-of-children-with-long-covid-accused-of-making-it-up/

    Hashtags:
    @longcovid
    @covid19

    Andy_European , to Random stuff
    @Andy_European@mastodon.online avatar

    Here we go again. Singapore CoViD19 cases almost double leading hospitals to cancel most elective procedures to free up bed capacity:

    The 🦠 pandemic is not even close to being over.

    https://www.channelnewsasia.com/singapore/singapore-covid-19-cases-nearly-double-hospital-capacity-vaccination-4345961?cid=internal_sharetool_ipad_18052024_cna

    anarchodelphis , to Random stuff
    @anarchodelphis@zeroes.ca avatar

    🧵 UPDATED: est.'d cases, the same per 100,000 pop. by health authority.

    According to wastewater data: on average, from 5/2 - 5/8, there would've been 1152 cases/day in (⬆️ 972, 4/25 - 5/1).

    https://anarchodelphis.tumblr.com/BCWastewater 1/4

    image/png

    anarchodelphis OP ,
    @anarchodelphis@zeroes.ca avatar

    UPDATED: Metro est.'d cases, wastewater load.

    According to wastewater data: on average, from 5/2 - 5/8, there would've been 203 & 687 cases/day in the Vancouver Coastal & Fraser HAs (⬆️ 165 & 578, 4/25 - 5/1).

    https://anarchodelphis.tumblr.com/BCWastewater 2/4

    image/png

    anarchodelphis OP ,
    @anarchodelphis@zeroes.ca avatar

    UPDATED: VIHA & IH est.'d cases, wastewater load.

    According to wastewater data: on average, from 5/3 - 5/9, there would've been 167 & 48 cases/day in the Vancouver Island & Interior HAs (⬆️ 131 & ⬇️ 62, 4/26 - 5/2).

    https://anarchodelphis.tumblr.com/BCWastewater 3/4

    image/png
    image/png
    image/png

    anarchodelphis OP ,
    @anarchodelphis@zeroes.ca avatar

    UPDATED: Northern Health est.'d cases, extrapolated from load.

    According to wastewater data: on average, from 5/2 - 5/8, there would've been 45 cases/day in Northern Health (⬆️ 38, 4/25 - 5/1).

    https://anarchodelphis.tumblr.com/BCWastewater 4/4

    image/png

    tomkindlon , to covid19 group
    @tomkindlon@disabled.social avatar

    New:
    Assessment of the Impact of RNase in Patients With Severe Fatigue Related to Post-Acute Sequelae of Infection ( ): A Randomized Phase 2 Trial of RSLV-132

    Free abstract:
    https://academic.oup.com/cid/article-abstract/doi/10.1093/cid/ciae205/7668392

    Hashtags:
    @longcovid

    @covid19 @novid @auscovid19

    1/

    tomkindlon OP ,
    @tomkindlon@disabled.social avatar

    2/

    “We hypothesized that removal of SARS-CoV-2 viral RNA from latent reservoirs may improve inflammation, neuroinflammation, and fatigue associated with post-acute sequelae of SARS-CoV-2 infection (PASC).”

    Hashtags:

    @longcovid


    @covid19 @novid @auscovid19

    tomkindlon , to covid19 group
    @tomkindlon@disabled.social avatar

    Small fibre neuropathy frequently underlies the painful syndrome

    https://journals.lww.com/pain/fulltext/9900/small_fibre_neuropathy_frequently_underlies_the.593.aspx

    "Clinical data, quantitative sensory testing, and skin biopsies were collected from 26 selected patients with painful long syndrome. (contd)”

    Hashtags:

    @longcovid

    @covid19

    1/

    tomkindlon , to longcovid group
    @tomkindlon@disabled.social avatar

    Cardiopulmonary Exercise Testing in Children With : A Case-controlled Study

    https://t.ly/Wb1ps

    "Children with have a reduced VO2 peak […], abnormal cardiovascular efficiency (VO2/HR% pred), pathological VE/VCO slope […], and abnormally reduced slope of VO2 work" "48% of the LC patients had a suspicious phenotype for pulmonary hypertension."

    Hashtags:
    @longcovid

    anarchodelphis , to Random stuff
    @anarchodelphis@zeroes.ca avatar

    UPDATED: variants.

    Of 69 samples from 4/28 - 5/4, LB.1 represented 10.1% (⬆️ 6.2% of 179, 4/21 - 4/27), KP.2.* 13% (⬆️ 8.9%, w.o. 4/21) & KP.3 8.7% (⬇️ 10.1%, w.o. 4/21).

    Of samples collected in B.C. on these weeks, the prevalence of these significant variants/lineages are as follows:

    • 4/28 - 5/4 -
      • JN.1.* (incl. JN.1.4., ".1.7., LB.1, JN.1.11.1, KP.1.1 - KP.3, KS.1, JN.1.16., ".1.18.2, ".1.20, ".1.26, ".1.30, ".1.32): 84.1%
      → JN.1.4.
      : 8.7%
      → LB.1: 10.1%
      → JN.1.11.1.* (incl. KP.1.1 - KP.3): 29%
      → KP.2.*: 13%
      → KP.3: 8.7%

    • 4/21 - 4/27 -
      • JN.1.* (incl. JN.1.1., ".1.4., ".1.7., ".1.8.1, LB.1, KP.1.1. - KP.4., JN.1.13.1, KS.1, JN.1.15, ".1.16., ".1.18, ".1.19, ".1.26, ".1.28, ".1.32.* - ".1.34, ".1.39, ".1.43, ".1.48.1): 88.8%
      → JN.1.4.: 7.3%
      → LB.1: 6.2%
      → JN.1.11.1.
      (only KP.1.1.* - KP.4.): 24.6%
      → KP.2.
      : 8.9%
      → KP.3: 10.1%

    X.X.* in text = X.X and its descendants.

    X.X.* in the graph = all descendants of strain X.X, except for ones that have their own segment of the week’s bar. Please see "Notes on Usage" section.

    https://anarchodelphis.tumblr.com/BCVariants

    currentbias , to Random stuff
    @currentbias@open-source-eschaton.net avatar

    The evidence that covid can dysregulate the immune system is — at this point — extensive, though not well-publicized. A close eye on covid-related subreddits will reveal — with surprising frequency — posts asking about, or describing, anecdotal experiences with this. Here are over a dozen:

    https://blog.open-source-eschaton.net/immune-dysregulation-reddit-edition

    EricCarroll , to Random stuff
    @EricCarroll@zeroes.ca avatar

    Another awesome analysis from

    Honesty About is Essential for Progress

    > Governments and certain key opinion formers aren’t being open and honest about the risks associated with COVID-19 and their actions will have long-term consequences for public health and trust in science.

    > The combination of a widely expressed receptor and persistent infection means the acute and long-term effects of , the virus which causes , can be unpredictable ... How many people are suffering the long-term sequelae of COVID-19 infection but not drawing the causal link and instead ascribing their new conditions to bad luck or aging?

    https://johnsnowproject.org/primers/honesty-about-covid-is-essential-for-progress/

    anarchodelphis , to Random stuff
    @anarchodelphis@zeroes.ca avatar

    UPDATED: variants.

    9 samples from 5/5 - 5/11 have been omitted. Of 159 from 4/28 - 5/4, KP.2.* represented 23.3% (⬆️ 18.8% of 133, 4/21 - 4/27), & KP.3.* 18.9% (⬇️ 20.3%, w.o. 4/21).

    Of the samples collected in Alberta on these weeks, the prevalence of significant variants/lineages are as follows:

    • 4/28 - 5/4 -
      • JN.1.* (incl. JN.1.1.6, "1.4., ".1.7, ".1.8.1, LB.1, JN.1.11.1, KP.1. - KP.4.1, JN.1.13.1, KS.1, JN.1.16., LA.1, JN.1.25.1, ".1.32): 96.9%
      → JN.1.4: 14.5%
      → JN.1.11.1.
      (incl. KP.1.* - KP.4.): 59.7%
      → KP.2.
      (incl. KP.2.1, KP.2.3): 23.3%
      → KP.3: 18.9%
      → KP.4.* (only KP.4.1): <2%

    • 4/21 - 4/27 -
      • JN.1.* (incl. JN.1.1.6, ".1.4., ".1.7, ".1.8.1, LB.1, JN.1.11.1, KP.1. - KP.4., JN.1.13.1, ".1.16., ".1.23, KU.2): 97%
      → JN.1.4.: 13.5%
      → JN.1.11.1.
      (incl. KP.1.* - KP.4.): 60.9%
      → KP.2.
      (incl. KP.2.1, KP.2.3): 18.8%
      → KP.3: 20.3%
      → KP.4.* (only KP.4.1, KP.4.2): 6.8%

    X.X.* in text = X.X & descendants.

    X.X.* in graph = all descendants of X.X, except for ones that have their own segment of the week’s bar. Please see "Notes on Usage" section.

    https://anarchodelphis.tumblr.com/ABVariants

    currentbias , to Random stuff
    @currentbias@open-source-eschaton.net avatar

    The fact that it was ever possible for to be universally persistent -- capable of establishing reservoirs in various tissues that are inaccessible to the immune system, remaining and replicating indefinitely, no matter how slowly (or vaccinated) in the chronic phase -- was the pit of dread in my stomach from the beginning. The burden of proof, for adherents of the precautionary principle, was always upon the assumption that the body can clear this virus in the first place

    anarchodelphis , to Random stuff
    @anarchodelphis@zeroes.ca avatar

    UPDATED: variants.

    12 samples from 5/5 - 5/11 have been omitted. Of 228 from 4/28 - 5/4, KP.2.* represented 10.5% (⬆️ 5% of 222, 4/21 - 4/27), & KP.3 31.1% (⬆️ 23.4%, w.o. 4/21).

    Of the samples collected in Ontario on these weeks, the prevalence of each of these significant variants/lineages are as follows:

    • 4/28 - 5/4 -
      • JN.1.* (incl. JN.1.1, ".1.2, ".1.4., ".1.7 - ".1.9.2, LB.1, JN.1.10, ".1.11.1, KP.1.1 - KP.3, JN.1.13, KS.1, JN.1.16., ".1.22, KW.1.1, JN.1.32, ".1.40): 97.8%
      → JN.1.4.: 14%
      → JN.1.11.1.
      (incl. KP.1.1.* - KP.3): 48.2%
      → KP.2.*: 10.5%
      → KP.3: 31.1%
      → KS.1: 4.8%

    • 4/21 - 4/27 -
      • JN.1.* (incl. JN.1.2, ".1.4., ".1.5, ".1.7, ".1.8.1, LB.1, ".1.10, ".1.11., KP.1.1 - KP.3, JN.1.13.1, KS.1, JN.1.16., ".1.18 - ".1.20, KW.1, JN.1.32, ".1.48.1): 92.3%
      → JN.1.4.
      : 12.6%
      → JN.1.11.* (incl. KP.1.1.* - KP.3): 35.6%
      → KP.2.* (incl. KP.2.3): 5%
      → KP.3: 23.4%
      → KS.1: 5.4%

    X.X.* in text denotes variant X.X and its descendants.

    X.X.* in the graph includes all descendants of strain X.X, except for ones that have their own segment of the week’s bar. Please see "Notes on Usage" section.

    https://anarchodelphis.tumblr.com/ONVariants

    tomkindlon , to covid19 group
    @tomkindlon@disabled.social avatar

    at Work: A Manager's Guide (Harvard Business Review)

    https://hbr.org/2024/05/long-covid-at-work-a-managers-guide
    (audio version also available at link)

    On adaptations that can be made by organisations to include employees with chronic illnesses

    Hashtags:
    @longcovid
    @covid19 @novid @auscovid19

    1/

    broadwaybabyto , to Random stuff
    @broadwaybabyto@zeroes.ca avatar

    The mask ban being proposed in North Carolina is discriminatory & dangerous. I’m grateful this clip covered the risk these bans pose to POC & marginalized individuals. It won’t be limited to people committing crimes…. If you truly believe that you need to listen to more marginalized voices.

    I found it especially telling that the senator mentioned “trusting” law enforcement not to arrest Granny for wearing a mask in Walmart. The de facto implication here is that they CAN arrest Granny for that. They may not be able to criminally charge you - but if they’re allowed to stop, search and arrest just for masking in public there will be abuse. There will be situations where people are forced to remove their mask and consent to a search AND risk infection.

    Im incredibly grateful to all the groups fighting back against this bill - and encourage everyone to watch this brief clip:

    https://www.youtube.com/embed/UIft1R9Ltvw

    tomkindlon , to AusCOVID19 group
    @tomkindlon@disabled.social avatar

    From Canada:

    An amyloidogenic fragment of the SARS CoV-2 envelope protein promotes serum amyloid A misfolding and fibrillization

    Free:
    https://www.biorxiv.org/content/biorxiv/early/2024/04/26/2024.04.25.591137.full.pdf

    Hashtags:
    @longcovid


    @covid19 @novid @auscovid19

    1/

    tomkindlon OP ,
    @tomkindlon@disabled.social avatar

    3/

    "our results suggest two possible pathways of fibrillization due to SARS-CoV-2 infection that are both fueled by a heightened innate inflammatory response."

    Hashtags:

    @longcovid


    @covid19 @novid @auscovid19

    tomkindlon , to AusCOVID19 group
    @tomkindlon@disabled.social avatar

    Persistence of SARS-CoV-2 in Platelets & Megakaryocytes in Long

    Free
    https://www.croiconference.org/abstract/persistence-of-sars-cov-2-in-platelets-and-megakaryocytes-in-long-covid/

    "In , persists and replicates in MKs that in turn produce platelets containing virus. (contd)”

    @longcovid

    @covid19 @auscovid19

    1/

    tomkindlon OP ,
    @tomkindlon@disabled.social avatar

    2/
    “(Contd) Circulating spike might be an additional sign of viral persistence that could serve as a biomarker. The persistence of the virus could lead to abnormal platelet activation and formation of microclots, contributing to the various symptoms observed in Long COVID and to deregulation of serotonin uptake"

    Hashtags:

    @longcovid


    @covid19 @novid

    tomkindlon , to MECFS group
    @tomkindlon@disabled.social avatar

    New US preprint:
    Oxidative Stress is a shared characteristic of ME/CFS and

    https://www.biorxiv.org/content/10.1101/2024.05.04.592477v1

    Authors include Ron Davis, Mark Davis & Hector Bonilla

    @mecfs

    tomkindlon OP ,
    @tomkindlon@disabled.social avatar

    2/
    “By studying bioenergetic characteristics of peripheral blood lymphocytes in over 16 healthy controls, 15 ME/CFS, & 15 , we find both & donors exhibit signs of elevated oxidative stress, relative to healthy controls, especially in the memory subset (contd)”

    Hashtags:

    @longcovid

    @covid19
    @mecfs

    tomkindlon OP ,
    @tomkindlon@disabled.social avatar
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