tomkindlon , to longcovid group
@tomkindlon@disabled.social avatar

Mitochondrial dysfunction in long : mechanisms, consequences, and potential therapeutic approaches

https://t.ly/zFOKl

"This review aims to synthesize current findings related to mitochondrial dysfunction in , exploring its implications for cellular energy deficits, oxidative stress, immune dysregulation, metabolic disturbances, and endothelial dysfunction."

@longcovid

anarchodelphis , to Random stuff
@anarchodelphis@zeroes.ca avatar

UPDATED: variants.

Of 122 samples from 4/28 - 5/4, KP.2.* represented 7.4% (⬇️ 7.9% of 354, 4/21 - 4/27), KP.3 30.3% (⬆️ 22.3%, w.o. 4/21), & KS.1 3.3% (〰️ 3.4%, w.o. 4/21).

Of the samples collected in Canada on these weeks, the prevalence of significant variants/lineages are as follows:

  • 4/28 - 5/4 -
    • JN.1.* (incl. JN.1.4., KV.2, JN.1.7, ".1.8.1, LB.1, JN.1.10, KP.1.1. - KP.3, JN.1.13, KS.1, JN.1.16., ".1.20, KW.1, JN.1.40): 96.7%
    → JN.1.4.
    : 19.7%
    → JN.1.11.1.* (incl. KP.1.1.* - KP.3): 42.6%
    → KP.2.*: 7.4%
    → KP.3: 30.3%
    → KS.1: 3.3%

  • 4/21 - 4/27 -
    • JN.1.* (incl. JN.1.1.6, ".1.2, ".1.4., ".1.5, ".1.7, ".1.8., LB.1, JN.1.10, ".1.11., KP.1.1. - KP.4., JN.1.13.1, KS.1, JN.1.16., ".1.18 - ".1.20, ".1.22 - ".1.24.1, KW.1, KU.2, JN.1.32, ".1.48.1): 94.1%
    → JN.1.4.: 12.4%
    → JN.1.11.1.
    (incl. KP.1.1.* - KP.4.): 39.8%
    → KP.2.
    : 7.9%
    → KP.3: 22.3%
    → KS.1: 3.4%

X.X.* in text = X.X & descendants.

X.X.* in graph = all descendants of X.X, except for ones that have their own segment of the week’s bar. Please see "Notes on Usage" section.

https://anarchodelphis.tumblr.com/CanadaVariants

anarchodelphis , to Random stuff
@anarchodelphis@zeroes.ca avatar

🧵1/4
UPDATED: estimated cases, the same per 100,000 pop. by health authority.

According to BCCDC data, on average, BC would've had 955 cases/day from 4/25 - 5/1 (⬆️ 877, 4/18 - 4/24).

https://anarchodelphis.tumblr.com/BCWastewater

image/png

anarchodelphis OP ,
@anarchodelphis@zeroes.ca avatar

🧵2/4
UPDATED: Metro estimated cases, load.

According to BCCDC ww. data, on average, there would've had 162 & 566 cases/day from 4/25 - 5/1 (⬇️ 179 & ⬆️ 465, 4/18 - 4/24), in the Vancouver Coastal & Fraser HAs.

https://anarchodelphis.tumblr.com/BCWastewater

image/png

anarchodelphis OP ,
@anarchodelphis@zeroes.ca avatar

🧵3/4
UPDATED: VIHA & IH estimated cases, load.

According to BCCDC ww. data, on average, there would've had 128 & 63 cases/day from 4/26 - 5/2 (⬇️ 147 & ⬆️ 49, 4/19 - 4/25), in the Island & Interior HAs.

https://anarchodelphis.tumblr.com/BCWastewater

image/png
image/png
image/png

anarchodelphis OP ,
@anarchodelphis@zeroes.ca avatar

🧵4/4
UPDATED: Northern Health estimated cases, extrapolated from load.

According to BCCDC ww. data, on average, there would've had 38 cases/day from 4/25 - 5/1 (⬇️ 43, 4/18 - 4/24), in the Northern HA.

https://anarchodelphis.tumblr.com/BCWastewater

image/png

currentbias , to Random stuff
@currentbias@open-source-eschaton.net avatar

Soliciting studies on dogs shedding (how much, how long)

Two studies I found claim that of what dogs do shed, none is culturable/infectious

From September 2020:
"We also confirm an earlier report that dogs do not replicate virus in the upper respiratory tract [...]"

https://www.pnas.org/doi/10.1073/pnas.2013102117

Which cites (from April 2020):
"... infectious virus was not detected in any swabs collected from any of these dogs."

https://www.science.org/doi/10.1126/science.abb7015

broadwaybabyto , to Random stuff
@broadwaybabyto@zeroes.ca avatar

Since Toronto hospitals (which were ground zero for SARS1) dropped mask mandates in favour of a “mask respected” policy - I’ve heard many stories of patients requesting HCWs mask & being told no or experiencing push back.

When there’s an imbalance of power & no recourse if HCW refuses… how can a “just ask” policy work? Expecting a patient to argue/beg/plead for the HCW to mask is completely unreasonable and leaves people unable to access safe care. If your polite request is being met with eye rolls and accusations of “anxiety”… it’s hardly a “mask respected” environment.

anarchodelphis , to Random stuff
@anarchodelphis@zeroes.ca avatar

UPDATED: variants.

The BCCDC did not release any data for 4/20 onwards. Of 152 samples from 4/14-4/20, KP.2.* represented 9.9% (⬆️ 3.8% of 157, 4/7 - 4/13), KP.3 6.6% (⬇️ 7.6%, w.o. 4/7), & KP.4.1 4% (⬇️ 8.3%, w.o. 4/7).

Of samples collected in B.C. on these weeks, the prevalence of these significant variants/lineages are as follows:

  • 4/14 - 4/20 -
    • JN.1.* (incl. JN.1.1., ".1.4., KV.2, JN.1.7., ".1.8., ".1.11.1, KP.1.1.* - KP.4., JN.1.13., ".1.19, ".1.26, ".1.32., ".1.34, ".1.38, ".1.48.): 92.1%
    → JN.1.4.: 11.8%
    → JN.1.11.1.
    (incl. KP.1.1.* - KP.4.* †): 30.9%
    → KP.2: 9.9%
    → KP.3: 6.6%
    → KP.4.1: 4%
    → JN.1.13.1: 4.6%

  • 4/7 - 4/13 -
    • JN.1.* (incl. JN.1.1., ".1.4., ".1.7.* - ".1.9, LB.1, JN.1.11.1, KP.1.1.* - KP.4.2, JN.1.13.1, ".1.16., ".1.18, ".1.19, ".1.26, ".1.28, KU.2, JN.1.31, ".1.32., ".1.34, ".1.39): 87.3%
    → JN.1.4.: 12.7%
    → JN.1.11.1.
    (only KP.1.1 - KP.4.2 †): 22.9%
    → KP.2: 3.8%
    → KP.3: 7.6%
    → KP.4.1: 8.3%
    → JN.1.13.1: 2.6%

† JN.1.11.1 <2%

X.X.* in text = X.X and its descendants.

X.X.* in the graph = all descendants of strain X.X, except for ones that have their own segment of the week’s bar. Please see "Notes on Usage" section.

https://anarchodelphis.tumblr.com/BCVariants

anarchodelphis , to Random stuff
@anarchodelphis@zeroes.ca avatar

UPDATED: variants.

Of 87 samples from 4/28 - 5/4, KP.2.* represented 8.1% (⬆️ KP.2.3 only: 2.8% of 215, 4/21 - 4/27), KP.3 26.4% (⬆️ 24.2%, w.o. 4/21), & KS.1 4.6% (⬇️ 5.6%, w.o. 4/21).

Of the samples collected in Ontario on these weeks, the prevalence of each of these significant variants/lineages are as follows:

  • 4/28 - 5/4 -
    • JN.1.* (incl. JN.1.4., ".1.7, ".1.8.1, LB.1, JN.1.10, KP.1.1. - KP.3, JN.1.13, KS.1, JN.1.16., KW.1.1, JN.1.40): 95.4%
    → JN.1.4.
    : 24.1%
    → JN.1.11.1.* (incl. KP.1.1.* - KP.3): 39.1%
    → KP.2.*: 8.1%
    → KP.3: 26.4%
    → KS.1: 4.6%

  • 4/21 - 4/27 -
    • JN.1.* (incl. JN.1.2, ".1.4., ".1.5, ".1.7, ".1.8.1, LB.1, JN.1.10, ".1.11., KP.1.1 - KP.3, JN.1.13.1, KS.1, JN.1.16., ".1.18 - ".1.20, KW.1, JN.1.32, ".1.48.1): 92.1%
    → JN.1.4.
    : 12.6%
    → JN.1.11.1.* (incl. KP.1.1.* - KP.3): 35.8%
    → KP.2.3 †: 2.8%
    → KP.3: 24.2%
    → KS.1: 5.6%

† Other KP.2.* <2%

X.X.* in text denotes variant X.X and its descendants.

X.X.* in the graph includes all descendants of strain X.X, except for ones that have their own segment of the week’s bar. Please see "Notes on Usage" section.

https://anarchodelphis.tumblr.com/ONVariants

anarchodelphis , to Random stuff
@anarchodelphis@zeroes.ca avatar

UPDATED (again): variants.

Still nothing from 4/28 onwards. Of 78 samples from 4/21 - 4/27, KP.2.* represented 23.1% (⬇️ 36.1% of 86, 4/14 - 4/20), & KP.3.* 21.8% (⬆️ 8.1%, w.o. 4/14).

Of the samples collected in Alberta on these weeks, the prevalence of significant variants/lineages are as follows:

  • 4/21 - 4/27 -
    • JN.1.* (incl. JN.1.1.6, ".1.4., ".1.7, ".1.8.1, LB.1, JN.1.11.1, KP.1. - KP.4., JN.1.13.1, ".1.23, KU.2): 97.4%
    → JN.1.4: 11.5%
    → JN.1.11.1.
    (incl. KP.1.* - KP.4.*): 66.7%
    → KP.2: 23.1%
    → KP.3: 21.8%
    → KP.4.2: 6.4%

  • 4/14 - 4/20 -
    • JN.1.* (incl. JN.1.1.6, ".1.4., ".1.7, ".1.8., ".1.11.1, KP.2.* - KP.4.1, JN.1.13.1, KS.1, JN.1.16., ".1.18, ".1.32): 97.7%
    → JN.1.4.
    : 10.5%
    → JN.1.11.1.* (incl. KP.2.* - KP.4.): 55.8%
    → KP.2.
    : 36.1%
    → KP.3: 8.1%
    → KP.4.2: 0%

X.X.* in text = X.X & descendants.

X.X.* in graph = all descendants of X.X, except for ones that have their own segment of the week’s bar. Please see "Notes on Usage" section.

https://anarchodelphis.tumblr.com/ABVariants

broadwaybabyto , to Random stuff
@broadwaybabyto@zeroes.ca avatar

One of the most devastating (and dangerous) parts of pandemic has been the politicization of masks. As an immunocompromised person - getting HCWs to mask was never a battle. Other people weren’t aggressive & unkind.

Now? People cough on me or label me anxious. It’s unsafe.

broadwaybabyto , to Random stuff
@broadwaybabyto@zeroes.ca avatar

A great article from Julia Doubleday about our failed pandemic response. “Forever reinfections” is not the way out of pandemic.

I weep for lack of common sense these days. Herd immunity is NOT coming to save us & I want to know how many infections people need to get before they realize?

https://www.thegauntlet.news/p/does-the-public-understand-that-variant

tomkindlon , to AusCOVID19 group
@tomkindlon@disabled.social avatar

: plasma levels of neurofilament light chain in mild patients with neurocognitive symptoms

https://www.nature.com/articles/s41380-024-02554-0

"pNfL levels are significantly higher in long patients with mild acute and neurocognitive symptoms when compared to HC"

1/

Hashtags:
@longcovid

@covid19 @novid @auscovid19

anarchodelphis , to Random stuff
@anarchodelphis@zeroes.ca avatar

UPDATED: variants.

Of 25 samples from 4/21 - 4/27, KP.2.* represented 20% (⬇️36.6% of 82, 4/14 - 4/20; ⬆️ 27.1% of 85, 4/7 - 4/13), & KP.3 28% (⬆️ 7.3%, w.o. 4/14; ⬇️ 14.1%, w.o. 4/7).

Of the samples collected in Alberta on these weeks, the prevalence of significant variants/lineages are as follows:

  • 4/21 - 4/27 (⚠️ few samples) -
    • JN.1.* (incl. JN.1.4., ".1.8.1, ".1.11.1, KP.2. - KP.4., JN.1.13.1): 96%
    → JN.1.4: 12%
    → JN.1.11.1.
    (incl. KP.2.* - KP.4.*): 76%
    → KP.2: 20%
    → KP.3: 28%

  • 4/14 - 4/20 -
    • JN.1.* (incl. JN.1.1.6, ".1.4., ".1.7, ".1.8., ".1.11.1, KP.2.* - KP.4., JN.1.11.1, ".1.13.1, KS.1, JN.1.16., ".1.18, ".1.32): 97.6%
    → JN.1.4.: 11%
    → JN.1.11.1.
    (incl. KP.2.* - KP.4.): 53.7%
    → KP.2.
    : 36.6%
    → KP.3: 7.3%

X.X.* in text = X.X & descendants.

X.X.* in graph = all descendants of X.X, except for ones that have their own segment of the week’s bar. Please see "Notes on Usage" section.

https://anarchodelphis.tumblr.com/ABVariants

tomkindlon , to AusCOVID19 group
@tomkindlon@disabled.social avatar

🧵
Economist Impact:
“An incomplete picture: understanding the burden of long

https://impact.economist.com/perspectives/health/incomplete-picture-understanding-burden-long-covid

A report on the impact of for the society, economy and health system.

@longcovid


@covid19 @novid @auscovid19

1/

anarchodelphis , to Random stuff
@anarchodelphis@zeroes.ca avatar

UPDATED: variants.

Only ON & NB provided data (45 samples) for 4/21 - 4/27. Of those, KP.2 represented <2% (⬇️ 9.2% of 273, 4/14 - 4/20; ⬆️ 8.6% of 545, 4/7 - 4/13), & KP.3 13.3% (⬇️ 16.5%, w.o. 4/14; ⬆️ 7.3%, w.o. 4.7).

Of the samples collected in Canada on these weeks, the prevalence of significant variants/lineages are as follows:

  • 4/21 - 4/27 (⚠️ Few samples; ON, NB only) -
    • JN.1.* (incl. JN.1, ".1.4, ".1.5, ".1.7, ".1.8.1, KP.1.1 - KP.3, JN.1.13.1, KS.1, JN.1.16., ".1.20, ".1.23): 95.6%
    → JN.1.4: 31%
    → JN.1.11.1.
    (incl. KP.1.1 - KP.3): 17.8%
    → KP.2: <2%
    → KP.3: 13.3%
    → KS.1: 4.4%

  • 4/14 - 4/20 -
    • JN.1.* (incl. JN.1.1., ".1.2, ".1.4., KV.2, JN.1.5, ".1.7.* - ".1.9, LB.1, JN.1.10, ".1.11.1, KP.1.1.* - KP.4., ".1.13., KS.1, JN.1.16., ".1.18 - ".1.20, ".1.22, ".1.23, KW.1., KU.2, JN.1.31, ".1.32., ".1.38, ".1.45, ".1.47, ".1.48): 91.2%
    → JN.1.4.
    : 15%
    → JN.1.11.1.* (incl. KP.1.1.* - KP.4.): 33%
    → KP.2.
    : 9.2%
    → KP.3: 16.5%
    → KS.1: 3.7%

X.X.* in text = X.X & descendants.

X.X.* in graph = all descendants of X.X, except for ones that have their own segment of the week’s bar. Please see "Notes on Usage" section.

https://anarchodelphis.tumblr.com/CanadaVariants

anarchodelphis , to Random stuff
@anarchodelphis@zeroes.ca avatar

🧵 UPDATED: estimated cases, the same per 100,000 pop. by health authority.

According to BCCDC data, in the whole of , there would've been 875 cases/day on average, 4/18 - 4/24 (⬆️ 617, 4/11 - 4/17).

https://anarchodelphis.tumblr.com/BCWastewater

image/png

anarchodelphis OP ,
@anarchodelphis@zeroes.ca avatar

UPDATED: Metro estimated cases, load.

According to BCCDC wastewater data, on average, there would've been 179 & 463 cases/day in the Vancouver Coastal & Fraser HAs, 4/18 - 4/24 (⬆️ 116 & 336, 4/11 - 4/17).

https://anarchodelphis.tumblr.com/BCWastewater

image/png

anarchodelphis OP ,
@anarchodelphis@zeroes.ca avatar

UPDATED: VIHA & IH estimated cases, load.

According to BCCDC wastewater data, on average, there would've been 147 & 49 cases/day in the Island & Interior HAs, 4/19 - 4/25 (⬆️ 100 & 39, 4/12 - 4/18).

https://anarchodelphis.tumblr.com/BCWastewater

image/png
image/png
image/png

anarchodelphis OP ,
@anarchodelphis@zeroes.ca avatar

UPDATED: NH estimated cases, extrapolated from load.

According to BCCDC wastewater data, on average, there would've been 44 cases/day in the Northern HA, 4/18 - 4/24 (⬆️ 34, 4/11 - 4/17).

anarchodelphis.tumblr.com/BCWastewater

image/png

broadwaybabyto , to Random stuff
@broadwaybabyto@zeroes.ca avatar

Disabled people are not ok. The pandemic has turned society against us (even more than before).

People were quietly ableist before. Now they’re openly hateful.

It was hard to access healthcare before. Now it’s impossible.

It was lonely before. Now it’s a pit of despair

It’s been an incredibly difficult 4 years for disabled and vulnerable individuals. We’ve had to endure terror of knowing we will be triaged out of medical care if system is overwhelmed, have DNRs forced on us & are witnessing aggressive expansion of medically assisted death

We’ve watched as the world clamours to get “back to normal” while completely leaving us behind. We are told to “just stay home” because people don’t want to push for clean air initiatives and can’t be bothered to mask.

Even in hospitals - the one place we have no choice but to go - masking is not required & you run the risk of being labeled difficult or anxious for requesting a HCW mask in your presence. We’re expected to just go along and risk our health & baseline for the comfort of others

When we speak up - we’re shouted down by people who are utterly convinced that the pandemic is over and there’s no risk. We’re told we’re wrong, exaggerating, hypochondriacs or worse. We endure endless trolling & criticism for just wanting to survive.

It didn’t used to be like this. Ableism has always existed - but it was never as aggressively in your face as it is now. People are experiencing trauma from Covid… and rather than cope with it they seem to be lashing out at disabled individuals.

I don’t know if it’s because many mitigations were sold as a means of protecting the vulnerable - or maybe it’s just because we represent a reality people can’t face.

That health is not a permanent state. That Covid is not over and that anyone can become disabled at any time

Whatever the reason - the result is the same. A society that treats disabled people as “less than”. That wants us out of sight & out of mind and that won’t do the bare minimum to protect us. That look the other way when we tell them eugenicist policies are going to end lives

It’s exhausting and terrifying and sad. I’m tired. We are ALL tired. Yet so many of us spend whatever incredibly limited energy we have continuing to advocate for safe public spaces, safe healthcare and an end to eugenics. We fight for equality. And we need allies.

Please remember this the next time you’re entering a public space without a mask. Or tempted to mock a vulnerable person for wearing one. Or accessing healthcare. If it’s easy for you access care - try and imagine how scary it would be if it wasn’t.

Try and have compassion and empathy for people who are different than you. Try and face the difficult truth that one day you too will be disabled - and when that day comes you will want to be treated better than we are currently being treated.

I promise you it’s far easier to advocate from a position of health & strength… so join us. Be our allies. Listen & believe us when we tell stories of unsafe spaces, eugenics and discrimination. Help us change things so that everyone will be better off. /end

anarchodelphis , to Random stuff
@anarchodelphis@zeroes.ca avatar

UPDATED: variants.

Of 80 samples from 4/14 - 4/20, KP.2 represented 13.8% (⬆️ 3.8% of 157, 4/7 - 4/13), KP.3 6.3% (⬇️7.6%, w.o. 4/7), KP.4.1 6.3% (⬇️ 8.3%, w.o. 4/7), & XDP.* 5% (8.3%, w.o. 4/7).


Of the samples collected in B.C. on these weeks, the prevalence of these significant variants/lineages are as follows:

  • 4/14 - 4/20 -
    • JN.1.* (incl. JN.1.1, ".1.4., KV.2, JN.1.7., ".1.8., ".1.11.1, KP.1.1 - KP.4.2, JN.1.13., ".1.19, KU.2, JN.1.32., ".1.38, ".1.45, ".1.48): 87.5%
    → JN.1.4.
    : 10%
    → JN.1.11.1.* (incl. KP.1.1 - KP.4.2): 31.3%
    → KP.2: 13.8%
    → KP.3: 6.3%
    → KP.4.1: 6.3%
    → JN.1.13.1: 7.5%
    → XDP.*: 5%

  • 4/7 - 4/13 -
    • JN.1.* (incl. JN.1.1., ".1.4., ".1.7.* - ".1.9, LB.1, JN.1.11.1, KP.1.1.* - KP.4.2, JN.1.13.1, ".1.16., ".1.18, ".1.19, ".1.26, ".1.28, KU.2, JN.1.31, ".1.32., ".1.34, ".1.39): 87.3%
    → JN.1.4.: 12.7%
    → JN.1.11.1.
    (only KP.1.1 - KP.4.2 †): 22.9%
    → KP.2: 3.8%
    → KP.3: 7.6%
    → KP.4.1: 8.3%
    → JN.1.13.1: 2.6%
    → XDP.*: 8.3%

† other JN.1.11.1.* <2%

X.X.* in text = X.X and its descendants.

X.X.* in the graph = all descendants of strain X.X, except for ones that have their own segment of the week’s bar. Please see "Notes on Usage" section.

https://anarchodelphis.tumblr.com/BCVariants

tomkindlon , to longcovid group
@tomkindlon@disabled.social avatar

New-ish research from India:

Quantitative Proteomics of Recovered Patients Identifies Long-Term Changes in Sperm Proteins Leading to Cellular Stress in Spermatozoa

https://link.springer.com/article/10.1007/s43032-024-01560-5

@longcovid


@covid19 @novid @auscovid19

1/

tomkindlon OP ,
@tomkindlon@disabled.social avatar

2/

"Though this is a preliminary study and the number of samples analyzed for differential proteomics is a limitation, alterations in the expression of various proteins and elevated MDA levels clearly portray the presence of oxidative stress in the spermatozoa as a long-term consequence of infection”

@longcovid

@covid19
@novid

anarchodelphis , to Random stuff
@anarchodelphis@zeroes.ca avatar

UPDATED: variants.

Of 31 samples from 4/21 - 4/27, KP.3 represented 19.4% (⬇️ 29.1 of 127, 4/14 - 4/20; ⬆️ 3.4% of 233, 4/7 - 4/13), & KS.1 6.5% (⬇️ 7.9%, w.o. 4/14; ⬇️ 11.6%, w.o. 4/7).


Of the samples collected in Ontario on these weeks, the prevalence of each of these significant variants/lineages are as follows:

  • 4/21 - 4/27 (few samples; %s likely inaccurate) -
    • JN.1.* (incl. JN.1.4, ".1.5, ".1.7, ".1.8.1, KP.1.1 - KP.3, JN.1.13.1, KS.1, JN.1.16.1): 96.8%
    → JN.1.4: 29%
    → JN.1.11.1.* (incl. KP.1.1 - KP.3): 25.8%
    → KP.3: 19.4%
    → KS.1: 6.5%

  • 4/14 - 4/20 -
    • JN.1.* (incl. JN.1.1.5, "1.2, ".1.4., KV.2, JN.1.5, ".1.7., ".1.8.1, LB.1, JN.1.10, KP.1.1.* - KP.4.1, JN.1.13.1, KS.1, JN.1.16., ".1.18, ".1.20, KW.1., JN.1.47): 93.1%
    → JN.1.4.: 13.4%
    → JN.1.11.1.
    (incl. KP.1.1.* - KP.4.1): 37.8%
    → KP.2: 3.2%
    → KP.3: 29.1%
    → KS.1: 7.9%

X.X.* in text denotes variant X.X and its descendants.

X.X.* in the graph includes all descendants of strain X.X, except for ones that have their own segment of the week’s bar. Please see "Notes on Usage" section.

https://anarchodelphis.tumblr.com/ONVariants

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